Article
NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.
Genes & development - 1 Mar 1994
Collart M A, Struhl K
Abstract excerpt
The yeast HIS3 TR and TC TATA elements support basal transcription, but only TR can respond to transcriptional activators. Four genes, NOT1(CDC39), NOT2(CDC36), NOT3, NOT4, act as general negative regulators and preferentially affect TC-dependent transcription. Allele-specific suppression, a two-...
Topics
- Base Sequence
- Cell Cycle Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Hydro-Lyases
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- TATA Box
- Transcription Factors
- Transcription, Genetic