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Article

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.

Genes & development - 1 Mar 1994

Collart M A, Struhl K

Abstract excerpt

The yeast HIS3 TR and TC TATA elements support basal transcription, but only TR can respond to transcriptional activators. Four genes, NOT1(CDC39), NOT2(CDC36), NOT3, NOT4, act as general negative regulators and preferentially affect TC-dependent transcription. Allele-specific suppression, a two-hybrid interaction, and biochemical confractionation suggest that NOT1 and NOT2 are nuclear proteins associated in a...

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Source

Identifiers

PMID: 7926748
DOI: 10.1101/gad.8.5.525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.PMID 7926748Read ↗

Characterization of NOT5 that encodes a new component of the Not protein complex.Semantic proximity Read ↗

The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit.Semantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.Semantic proximity Read ↗

Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP).Semantic proximity Read ↗

The essential function of Not1 lies within the Ccr4-Not complex.Semantic proximity Read ↗

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.Semantic proximity Read ↗

The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.Semantic proximity Read ↗

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.Semantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAsSemantic proximity Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

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