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Article

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.

Journal of molecular biology - 7 Dec 2001

Chen J, Rappsilber J, Chiang Y C, Russell P, Mann M, Denis C L

Abstract excerpt

The CCR4-NOT complex is an evolutionarily conserved, transcriptional regulatory complex that is involved in controlling mRNA initiation, elongation and degradation. The CCR4-NOT proteins from Saccharomyces cerevisiae exist in two complexes, 1.9x10(6) Da and 1.0x10(6) Da (1.0 MDa) in size, and individual components of these complexes display such disparate functions as binding to and restricting TFIID functions,...

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Source

Identifiers

PMID: 11733989
DOI: 10.1006/jmbi.2001.5162

Genes

CCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.PMID 11733989Read ↗

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.Semantic proximity Read ↗

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.Semantic proximity Read ↗

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.Semantic proximity Read ↗

Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.Semantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila.Semantic proximity Read ↗

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAsSemantic proximity Read ↗

The Ccr4-Not complex interacts with the mRNA export machinery.Semantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

The essential function of Not1 lies within the Ccr4-Not complex.Semantic proximity Read ↗

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complexSemantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

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