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Article

Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers.

Toxicology - 24 Sept 2007

Hsieh Hui-I, Chen Pau-Chung, Wong Ruey-Hong, Wang Jung-Der, Yang Pei-Ming, Cheng Tsun-Jen

Abstract excerpt

Although a relationship between vinyl chloride monomer (VCM) and liver cirrhosis has been reported, the underlying mechanisms are not clear. Cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase theta 1 (GSTT1) enzymes are involved in activation and detoxification of VCM, and thus may be important determinants of interindividual susceptibility to VCM-induced liver damage,...

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Source

Identifiers

PMID: 17659824
DOI: 10.1016/j.tox.2007.06.089

Genes

ALDH2
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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