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Article

The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.

Journal of human genetics - 1 Jan 2007

Schindler Jennifer, Li Yongliang, Marion Marie-Jeanne, Paroly Arianne, Brandt-Rauf Paul W

Abstract excerpt

Vinyl chloride (VC) is a human carcinogen known to undergo metabolism by cytochrome P450 2E1 (CYP2E1) to reactive intermediates that can cause oncogene and tumor suppressor gene mutations and that are further metabolized by acetaldehyde dehydrogenase (ALDH2) and glutathione-S-transferases (GSTs) to non-mutagenic end products. These metabolic enzymes have known polymorphisms that could lead to increased levels of...

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Source

Identifiers

PMID: 17384900
DOI: 10.1007/s10038-007-0134-5

Genes

ALDH2
GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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