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Article

A comparative study of molecular characteristics of pathogenic and uncertain significance variants of BRCA1/2 in Chinese breast cancer patients.

BMC research notes - 20 Apr 2026

Guan Jiayu, Hu Jiamei, Lin Sihang, Chen Chen, Luo Yuwei, Zhou Wenbin

Abstract excerpt

OBJECTIVE: Although many studies focus on breast cancer patients carrying pathogenic or likely pathogenic variants (P/LPVs) of the breast cancer susceptibility gene (BRCA), the impact of variants of uncertain significance (VUS) on breast cancer remains unclear. This study aims to analyze the tumor biological characteristics of different mutation types of the BRCA in the Shenzhen population. RESULTS: (1) Among the...

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Identifiers

PMID: 42010629
DOI: 10.1186/s13104-026-07827-1
PMCID: PMC13227675

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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