Article
Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin.
Stem cells (Dayton, Ohio) - 1 Feb 2007
Sonntag Kai-Christian, Pruszak Jan, Yoshizaki Takahito, van Arensbergen Joris, Sanchez-Pernaute Rosario, Isacson Ole
Abstract excerpt
It is currently not known whether dopamine (DA) neurons derived from human embryonic stem cells (hESCs) can survive in vivo and alleviate symptoms in models of Parkinson disease (PD). Here, we report the use of Noggin (a bone morphogenic protein antagonist) to induce neuroectodermal cell developm...
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