Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation.

Abstract excerpt

We describe a hierarchical regression modeling approach to selection of a subset of markers from the first stage of a genomewide association scan to carry forward to subsequent stages for testing on an independent set of subjects. Rather than simply selecting a subset of most significant marker-disease associations at some cutoff chosen to maximize the cost efficiency of a multistage design, we propose a prior...

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