Article
A latent model for prioritization of SNPs for functional studies.
PloS one - 1 Jan 2011
Fridley Brooke L, Iversen Ed, Tsai Ya-Yu, Jenkins Gregory D, Goode Ellen L, Sellers Thomas A
Abstract excerpt
One difficult question facing researchers is how to prioritize SNPs detected from genetic association studies for functional studies. Often a list of the top M SNPs is determined based on solely the p-value from an association analysis, where M is determined by financial/time constraints. For many studies of complex diseases, multiple analyses have been completed and integrating these multiple sets of results may...
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