Article
Evaluating strategies for marker ranking in genome-wide association studies of complex traits.
Methods of information in medicine - 1 Jan 2010
Scherag A, Hebebrand J, Wichmann H-E, Jöckel K-H
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) were highly successful in identifying new susceptibility loci of complex traits. Such studies usually start with genotyping fixed arrays of genetic markers in an initial sample. Out of these markers, some are selected which will be further genotyped in independent samples. Due to the very low a priori probability of a true positive association, the vast majority...
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