Article
Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium.
American journal of human genetics - 7 Sept 2012
Zhu Qianqian, Ge Dongliang, Heinzen Erin L, Dickson Samuel P, Urban Thomas J, Zhu Mingfu, Maia Jessica M, He Min, Zhao Qian, Shianna Kevin V, Goldstein David B
Abstract excerpt
To date, the widely used genome-wide association studies (GWASs) of the human genome have reported thousands of variants that are significantly associated with various human traits. However, in the vast majority of these cases, the causal variants responsible for the observed associations remain unknown. In order to facilitate the identification of causal variants, we designed a simple computational method called...
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