Article
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.
Human genetics - 1 Jul 1998
Yoshimura M, Yasue H, Nakayama M, Shimasaki Y, Sumida H, Sugiyama S, Kugiyama K, Ogawa H, Ogawa Y, Saito Y, Miyamoto Y, Nakao K
Abstract excerpt
Coronary spasm plays an important role in the pathogenesis of not only variant angina but also ischemic heart disease in general. However, the precise mechanism(s) by which coronary spasm occurs remains to be elucidated. Coronary spasm may arise from interactions between environmental and genetic...
Topics
- Adult
- Aged
- Amino Acid Substitution
- Aspartic Acid
- Coronary Vasospasm
- Exons
- Female
- Genes, Dominant
- Genetic Variation
- Glutamic Acid
- Heterozygote
- Homozygote
- Humans
- Japan
- Male
- Middle Aged