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Article

A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.

Human genetics - 1 Jul 1998

Yoshimura M, Yasue H, Nakayama M, Shimasaki Y, Sumida H, Sugiyama S, Kugiyama K, Ogawa H, Ogawa Y, Saito Y, Miyamoto Y, Nakao K

Abstract excerpt

Coronary spasm plays an important role in the pathogenesis of not only variant angina but also ischemic heart disease in general. However, the precise mechanism(s) by which coronary spasm occurs remains to be elucidated. Coronary spasm may arise from interactions between environmental and genetic factors. Endothelial-derived nitric oxide (NO) has been implicated in the control of vascular tone. We have recently...

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Identifiers

PMID: 9737779
DOI: 10.1007/s004390050785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.PMID 9737779Read ↗

The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm.Semantic proximity Read ↗

T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.Semantic proximity Read ↗

Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.Semantic proximity Read ↗

Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants.Semantic proximity Read ↗

A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis.Semantic proximity Read ↗

Association of endothelial nitric oxide synthase (Glu298Asp) gene polymorphism with radial artery spasm during cardiac catheterization in Egyptians.Semantic proximity Read ↗

Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene.Semantic proximity Read ↗

T(-786)--> C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis.Semantic proximity Read ↗

Endothelial nitric oxide synthase gene is positively associated with essential hypertension.Semantic proximity Read ↗

A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.Semantic proximity Read ↗

Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.Semantic proximity Read ↗

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