Article
Single-strand conformation polymorphism analysis on the delta-sarcoglycan gene in Japanese patients with hypertrophic cardiomyopathy.
The American journal of cardiology - 1 Jun 2000
Date M, Otsu K, Nishida K, Toyofuku T, Matsumura Y, Morita T, Hirotani S, Okazaki Y, Hayashizaki Y, Nigro V, Kuzuya T, Tada M, Hori M
Abstract excerpt
To elucidate the etiology of hypertrophic cardiomyopathy (HC) in humans, we analyzed the delta-sarcoglycan gene (SG), which is reported to be the causal gene for HC in the Syrian hamster BIO14.6. We performed polymerase chain reaction (PCR) single-strand conformation polymorphism (SSCP) and nucleotide sequence analyses on the delta-SG in 102 patients with HC. SSCP was detected in exon 2 of the gene, but not in...
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