Article
Nuclear matrix binding regulates SATB1-mediated transcriptional repression.
The Journal of biological chemistry - 1 Jul 2005
Seo Jin, Lozano Mary M, Dudley Jaquelin P
Abstract excerpt
Special AT-rich binding protein 1 (SATB1) originally was identified as a protein that bound to the nuclear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhancer. Subsequently, SATB1 was shown to repress many genes expressed in the thymus, including interleukin-2 receptor alpha, c-myc, and those encoded by mouse mammary tumor virus (MMTV), a glucocorticoid-responsive retrovirus....
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