Article

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain

2019-03-18

Abstract excerpt

MeCP2 is an abundant protein, involved in transcriptional repression by binding to CG and non-CG methylated DNA. However, MeCP2 might also function as a transcription activator as MeCP2 is found bound to sparsely methylated promoters of actively expressed genes. Furthermore, Attachment Region Binding Protein (ARBP), the chicken ortholog of MeCP2, has been reported to bind to Matrix/scaffold attachment regions (MAR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69971913-cc05-591d-a964-bf67b78da8e4
DOI: 10.1101/581934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domainDOI 10.1101/581934Read

MeCP2: structure and function.Semantic proximity Read

Methyl-CpG Binding Protein 2 Reads Histone Methylation via an Aromatic Cage to Regulate Gene Expression and Chromatin AssociationSemantic proximity Read

Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2.Semantic proximity Read

MECP2 MBD-ID Module: A Unified DNA/RNA Binding Interface Disrupted in Rett SyndromeSemantic proximity Read

MeCP2: the chromatin connection and beyond.Semantic proximity Read

Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2.Semantic proximity Read

MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.Semantic proximity Read

Solution structure of the matrix attachment region-binding domain of chicken MeCP2.Semantic proximity Read

Conformational flexibility and rotational binding shifts in W104C mutant MECP2-DNA complexes: A molecular simulation study.Semantic proximity Read

Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction.Semantic proximity Read

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2Semantic proximity Read

Phylogenetic Profiling and Disordered Region Assessment of MECP2, CDKL5, and FOXG1 to Reveal Strategies for Rett Syndrome TreatmentSemantic proximity Read