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Article

Differential requirement of unfolded protein response pathway for calreticulin expression in Caenorhabditis elegans.

Journal of molecular biology - 14 Sept 2007

Lee Dukgyu, Singaravelu Gunasekaran, Park Byung-Jae, Ahnn Joohong

Abstract excerpt

Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR) pathway, which increases the expression of chaperones to maintain the homeostasis. Calreticulin is a calcium-binding chaperone located in the lumen of endoplasmic reticulum (ER). Here we show that in response to a UPR inducing reagent, tunicamycin, the expression of calreticulin (crt-1) is specifically...

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Identifiers

PMID: 17651753
DOI: 10.1016/j.jmb.2007.06.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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