Article

Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease

2023-10-06

Abstract excerpt

Alveolarization ensures sufficient lung surface area for gas exchange, and during bulk alveolarization in mice (postnatal day [P] 4.5-14.5), alpha-smooth muscle actin (SMA) + myofibroblasts accumulate, secrete elastin, and lay down alveolar septae. Herein, we delineate the dynamics of the lineage of early postnatal SMA + myofibroblasts during and after bulk alveolarization and in response to lung injury. SMA +...

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Literature Corpus work: fe91a9da-82c2-5138-89d3-7c67e7e988a2
DOI: 10.1101/2023.10.04.560924

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