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Article

The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2007

Miyairi Isao, Tatireddigari Venkat R R Arva, Mahdi Olaimatu S, Rose Lorne A, Belland Robert J, Lu Lu, Williams Robert W, Byrne Gerald I

Abstract excerpt

C57BL/6J mice were 10(5)-fold more resistant to Chlamydia psittaci infection than DBA/2J mice by LD(100) determinations. Linkage analysis using BXD recombinant inbred strains revealed a single effector locus at a 1.5-Mbp region on chromosome 11 encoding a cluster of three p47 GTPases (Irgb10, Igtp, and Iigp2). Western blots of infected tissue showed that Irgb10 was elevated in resistant mice and one of the two...

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Identifiers

PMID: 17641048
DOI: 10.4049/jimmunol.179.3.1814

Genes

CXCR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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