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Article

Balance of Irgm protein activities determines IFN-gamma-induced host defense.

Journal of leukocyte biology - 1 May 2009

Henry Stanley C, Daniell Xiaoju G, Burroughs Ashley R, Indaram Maanasa, Howell David N, Coers Jörn, Starnbach Michael N, Hunn Julia P, Howard Jonathan C, Feng Carl G, Sher Alan, Taylor Gregory A

Abstract excerpt

The immunity-related GTPases (IRG), also known as p47 GTPases, are a family of proteins that are tightly regulated by IFNs at the transcriptional level and serve as key mediators of IFN-regulated resistance to intracellular bacteria and protozoa. Among the IRG proteins, loss of Irgm1 has the most profound impact on IFN-gamma-induced host resistance at the physiological level. Surprisingly, the losses of host...

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Identifiers

PMID: 19176402
DOI: 10.1189/jlb.1008599
PMCID: PMC2669409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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