Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms.

PloS one - 1 Jan 2012

Miyairi Isao, Ziebarth Jesse, Laxton Jonathan D, Wang Xiaofei, van Rooijen Nico, Williams Robert W, Lu Lu, Byrne Gerald I, Cui Yan

Abstract excerpt

Genetic mapping studies may provide association between sequence variants and disease susceptibility that can, with further experimental and computational analysis, lead to discovery of causal mechanisms and effective intervention. We have previously demonstrated that polymorphisms in immunity-related GTPases (IRG) confer a significant difference in susceptibility to Chlamydia psittaci infection in BXD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Host-Pathogen Interactions

Share to Macrophages

Share to Mice, Inbred Strains

Share to Neutrophils

Share to Weight Loss

Source

Open in PubMed Open full text

Identifiers

PMID: 22438999
DOI: 10.1371/journal.pone.0033781
PMCID: PMC3306297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms.PMID 22438999Read ↗

The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection.Semantic proximity Read ↗

Chlamydia psittaci: New insights into genomic diversity, clinical pathology, host–pathogen interaction and anti-bacterial immunitySemantic proximity Read ↗

Genetic diversity of Collaborative Cross mice enables the establishment of a novel <i>Chlamydia muridarum</i> female genital tract infection modelSemantic proximity Read ↗

Irgm proteins attenuate inflammatory disease in mouse models of genital <i>Chlamydia</i> infectionSemantic proximity Read ↗

MicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in Mice.Semantic proximity Read ↗

Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection.Semantic proximity Read ↗

Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism.Semantic proximity Read ↗

Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse.Semantic proximity Read ↗

Chlamydia psittaci genetic variants differ in virulence by modulation of host immunity.Semantic proximity Read ↗

Icsbp1 /IRF-8 Is Required for Innate and Adaptive Immune Responses against Intracellular PathogensSemantic proximity Read ↗

Complex genetics architecture contributes to Salmonella resistance in AcB60 mice.Semantic proximity Read ↗

Identification of an immune modulation locus utilising a bovine mammary gland infection challenge model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.