Article
High-resolution melting amplicon analysis as a method to detect c-kit and platelet-derived growth factor receptor alpha activating mutations in gastrointestinal stromal tumors.
American journal of clinical pathology - 1 Aug 2007
Holden Joseph A, Willmore-Payne Carlynn, Coppola Domenico, Garrett Christopher R, Layfield Lester J
Abstract excerpt
High-resolution melting amplicon analysis (HRMAA) was used to detect c-kit and platelet-derived growth factor receptor alpha (PDGFRA) activating mutations in 96 gastrointestinal stromal tumors (GISTs). HRMAA detected mutations in 87 GISTs (91%). Of the 87 cases, 69 (79%) contained c-kit mutations...
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