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Article

Molecular analysis of c-Kit and PDGFRA in GISTs diagnosed by EUS.

American journal of clinical pathology - 1 Jan 2007

Gomes Ana L, Bardales Ricardo H, Milanezi Fernanda, Reis Rui M, Schmitt Fernando

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are characterized by overexpression and mutations of c-Kit. Approximately 80% of c-Kit mutations occur in exon 11, being a response factor to imatinib (Gleevec) therapy. Mutations of platelet-derived growth factor receptor-alpha (PDGFRA) are observed in a subset of GISTs lacking c-Kit mutations.We aimed to assess whether c-Kit and PDGFRA mutation analysis of GISTs obtained...

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Source

Identifiers

PMID: 17145623
DOI: 10.1309/M1EC8JE9ACAMJACU

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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