Article
High-resolution melting analysis is a sensitive diagnostic tool to detect imatinib-resistant and imatinib-sensitive PDGFRA exon 18 mutations in gastrointestinal stromal tumors.
Human pathology - 1 Mar 2014
Künstlinger Helen, Binot Elke, Merkelbach-Bruse Sabine, Huss Sebastian, Wardelmann Eva, Buettner Reinhard, Schildhaus Hans-Ulrich
Abstract excerpt
The mutational status of KIT and PDGFRA is highly relevant for prognosis and therapy prediction in gastrointestinal stromal tumors (GIST). PDGFRA exon 18 mutations have direct therapeutic implications since it is crucial to distinguish mutations associated with sensitivity to tyrosine kinase inhibitors from those causing primary resistance, eg, the most common exon 18 mutation p.D842V. In response to a growing...
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