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Article

Positive selection on a human-specific transcription factor binding site regulating IL4 expression.

Current biology : CB - 2 Dec 2003

Rockman Matthew V, Hahn Matthew W, Soranzo Nicole, Goldstein David B, Wray Gregory A

Abstract excerpt

A single nucleotide polymorphism in the promoter of the multifunctional cytokine Interleukin 4 (IL4) affects the binding of NFAT, a key transcriptional activator of IL4 in T cells. This regulatory polymorphism influences the balance of cytokine signaling in the immune system, with important consequences-positive and negative-for human health. We determined that the NFAT binding site is unique to humans; it arose...

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Identifiers

PMID: 14654003
DOI: 10.1016/j.cub.2003.11.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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