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Article

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

PloS one - 1 Jan 2014

Lancaster Graeme I, Kraakman Michael J, Kammoun Helene L, Langley Katherine G, Estevez Emma, Banerjee Ashish, Grumont Raelene J, Febbraio Mark A, Gerondakis Steve

Abstract excerpt

Alterations in the immune cell profile and the induction of inflammation within adipose tissue are a hallmark of obesity in mice and humans. Dual-specificity phosphatase 2 (DUSP2) is widely expressed within the immune system and plays a key role promoting immune and inflammatory responses dependent on mitogen-activated protein kinase (MAPK) activity. We hypothesised that the absence of DUSP2 would protect mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25375135
DOI: 10.1371/journal.pone.0111524
PMCID: PMC4222916

Genes

DUSP2
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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