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Article

Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.

Carcinogenesis - 1 Sept 2007

Chen Kexin, Hu Zhibin, Wang Li-E, Sturgis Erich M, El-Naggar Adel K, Zhang Wei, Wei Qingyi

Abstract excerpt

Tumor protein 53 (TP53), a transcriptional factor, induces expression of the B-cell lymphoma 2-associated X protein (BAX) gene by directly binding to the TP53-binding element in the BAX promoter but inhibits B-cell lymphoma 2 (BCL2) promoter-driven transcription through a responsive region in the BCL2 promoter. Therefore, we hypothesized that single-nucleotide polymorphisms (SNPs) of BAX and BCL2 promoters and...

Read the complete abstract on PubMed

Topics

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Share to bcl-2-Associated X Protein
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-bcl-2

Share to Reference Values

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17693666
DOI: 10.1093/carcin/bgm172

Genes

BAX
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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