Article
T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.
PloS one - 1 Jan 2014
Sanchez-Lockhart Mariano, Rojas Ana V, Fettis Margaret M, Bauserman Richard, Higa Trissha R, Miao Hongyu, Waugh Richard E, Miller Jim
Abstract excerpt
T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse. Coordination of the activation, recruitment, and signaling from T cell receptor (TCR) in conjunction with adhesion and costimulatory receptors regulates both the initiation and duration of...
Topics
- Animals
- B7-1 Antigen
- CD28 Antigens
- Ligands
- Lymphocyte Activation
- Mice
- Mice, Transgenic
- Molecular Dynamics Simulation
- Mutation
- Receptors, Antigen, T-Cell
- Recombinant Fusion Proteins
- Signal Transduction
- T-Lymphocytes