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Article

Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network.

Neuroreport - 6 Aug 2007

Alpár Alán, Ueberham Uwe, Seeger Gudrun, Arendt Thomas, Gärtner Ulrich

Abstract excerpt

Alzheimer's disease is characterized by severe neuronal disintegration supposed to be partly associated with amyloid pathology. Recently, we described morphological alterations of pyramidal cell structure in transgenic mice expressing wild-type or mutant human amyloid precursor protein (hAPP) (strains B6-Py8.9 and Tg2576), which are unrelated to direct plaque-associated changes. In this study, we focused on the...

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PMID: 17632276
DOI: 10.1097/WNR.0b013e3282202829

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