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Article

SRF deletion results in earlier disease onset in a mouse model of amyotrophic lateral sclerosis

20 Jun 2023

Abstract excerpt

Changes in neuronal activity modulate the vulnerability of motoneurons (MNs) in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). So far, the molecular basis of neuronal activity's impact in ALS is poorly understood. Herein, we investigated the impact of deleting the neuronal activity-stimulated transcription factor (TF) serum response factor (SRF) in MNs of SOD1G93A mice. SRF was present...

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PMID: 37339001
DOI: 10.1172/jci.insight.167694

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