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Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

2023-10-02

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Mitochondrial dysfunction such as excess production of reactive oxygen species (ROS) and defective mitochondrial dynamics are common features of C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS/FTD), but it remains unclear whether these are causative or a consequence of the pathogenic process. To address this, we have performed a comprehensive characterisation of mitochondrial dysfunction in vi...

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Literature Corpus work: 23d9f04d-fa43-5296-a686-1be0179595e1
DOI: 10.1101/2023.10.02.560439

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Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in <i>C9orf72</i> ALS/FTD <i>in vivo</i> models and patient iNeurons

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