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Article

Progressive spinal axonal degeneration and slowness in ALS2-deficient mice.

Annals of neurology - 1 Jul 2006

Yamanaka Koji, Miller Timothy M, McAlonis-Downes Melissa, Chun Seung Joo, Cleveland Don W

Abstract excerpt

OBJECTIVE: Homozygous mutation in the ALS2 gene and the resulting loss of the guanine exchange factor activity of the ALS2 protein is causative for autosomal recessive early-onset motor neuron disease that is thought to predominantly affect upper motor neurons. The goal of this study was to elucidate how the motor system is affected by the deletion of ALS2. METHODS: ALS2-deficient mice were generated by gene...

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Share to Guanine Nucleotide Exchange Factors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16802286
DOI: 10.1002/ana.20888

Genes

ALS2
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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