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Article

Progressive spinal axonal degeneration and slowness in ALS2-deficient mice.

Annals of neurology - 1 Jul 2006

Yamanaka Koji, Miller Timothy M, McAlonis-Downes Melissa, Chun Seung Joo, Cleveland Don W

Abstract excerpt

OBJECTIVE: Homozygous mutation in the ALS2 gene and the resulting loss of the guanine exchange factor activity of the ALS2 protein is causative for autosomal recessive early-onset motor neuron disease that is thought to predominantly affect upper motor neurons. The goal of this study was to eluci...

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Share to Guanine Nucleotide Exchange Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16802286
DOI: 10.1002/ana.20888

Genes

ALS2
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16802286-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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