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Early derangement of axonal mitochondria occurs in a mouse model of progressive but not relapsing-remitting multiple sclerosis

23 Jan 2023

Abstract excerpt

Derangement of axonal mitochondrial bioenergetics occurs during progressive multiple sclerosis (PMS). However, whether this is a delayed epiphenomenon or an early causative event of disease progression waits to be understood. Answering this question might further our knowledge of mechanisms underlying neurobiology of PMS and related therapy. MOG35–55-immunized NOD and PLP139–151-immunized SJL female mice were...

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PMID: 36702320
DOI: 10.1016/j.nbd.2023.106015

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