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Article

Combinatorial ShcA docking interactions support diversity in tissue morphogenesis.

Science (New York, N.Y.) - 13 Jul 2007

Hardy W Rod, Li Lingying, Wang Zhi, Sedy Jiri, Fawcett James, Frank Eric, Kucera Jan, Pawson Tony

Abstract excerpt

Changes in protein-protein interactions may allow polypeptides to perform unexpected regulatory functions. Mammalian ShcA docking proteins have amino-terminal phosphotyrosine (pTyr) binding (PTB) and carboxyl-terminal Src homology 2 (SH2) domains, which recognize specific pTyr sites on activated receptors, and a central region with two phosphorylated tyrosine-X-asparagine (pYXN) motifs (where X represents any...

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Identifiers

PMID: 17626887
DOI: 10.1126/science.1140114
PMCID: PMC2575375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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