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Article

Impairment of infectivity and immunoprotective effect of a LYT1 null mutant of Trypanosoma cruzi.

Infection and immunity - 1 Jan 2008

Zago M Paola, Barrio Alejandra B, Cardozo Rubén M, Duffy Tomás, Schijman Alejandro G, Basombrío Miguel A

Abstract excerpt

Trypanosoma cruzi infection of host cells is a complex process in which many proteins participate but only a few of these proteins have been identified experimentally. One parasite factor likely to be involved is the protein product of LYT1, a single-copy gene cloned, sequenced, and characterized by Manning-Cela et al. (Infect. Immun. 69:3916-3923, 2001). This gene was potentially associated with infectivity,...

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Identifiers

PMID: 17938222
DOI: 10.1128/IAI.00400-07
PMCID: PMC2223657

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