Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence

13 Apr 2015

Abstract excerpt

BACKGROUND: The neglected parasitic infection Chagas disease is rapidly becoming a globalised public health issue due to migration. There are only two anti-parasitic drugs available to treat this disease, benznidazole and nifurtimox. Thus it is important to identify and validate new drug targets in Trypanosoma cruzi, the causative agent. T. cruzi expresses an ER-localised ascorbate-dependent peroxidase (TcAPx)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasites and Host Interactions
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25875298
DOI: 10.1371/journal.pntd.0003707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of VirulencePMID 25875298Read ↗

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.Semantic proximity Read ↗

Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulenceSemantic proximity Read ↗

Ascorbate peroxidase modulation confirms key role in Leishmania infantum oxidative defenceSemantic proximity Read ↗

The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivitySemantic proximity Read ↗

A panel of phenotypically and genotypically diverse bioluminescent:fluorescent <i>Trypanosoma cruzi</i> strains as a resource for Chagas disease researchSemantic proximity Read ↗

Disparate phenotypic effects from the knockdown of various Trypanosoma brucei cytochrome c oxidase subunits.Semantic proximity Read ↗

Bioluminescence imaging of chronic <scp> <i>T</i> </scp> <i>rypanosoma cruzi</i> infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent infectionSemantic proximity Read ↗

The cytosolic tryparedoxin peroxidase from Trypanosoma cruzi induces a pro-inflammatory Th1 immune response in a peroxidatic cysteine-dependent manner.Semantic proximity Read ↗

Dual and Opposite Roles of Reactive Oxygen Species (ROS) in Chagas Disease: Beneficial on the Pathogen and Harmful on the HostSemantic proximity Read ↗

Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility.Semantic proximity Read ↗

Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populationsSemantic proximity Read ↗

Ascorbate peroxidase from Leishmania major controls the virulence of infective stage of promastigotes by regulating oxidative stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.