Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GTP-dependent recruitment of CIITA to the class II major histocompatibility complex promoter.

The Journal of biological chemistry - 7 Sept 2007

Bewry Nadine N, Bolick Sophia C E, Wright Kenneth L, Harton Jonathan A

Abstract excerpt

We previously established that the class II transactivator CIITA binds GTP and disruption of the GTP binding ability of CIITA results in increased cytoplasmic CIITA, loss of nuclear CIITA, and thus diminished class II major histocompatibility complex transcription. Because of its role in facilitating nuclear localization, whether GTP binding is also required for CIITA-mediated transactivation of major...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to CREB-Binding Protein

Share to Cytoplasm

Share to Guanosine Triphosphate

Share to HLA-DR Antigens

Share to p300-CBP Transcription Factors

Source

Identifiers

PMID: 17623662
DOI: 10.1074/jbc.M611747200

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

GTP-dependent recruitment of CIITA to the class II major histocompatibility complex promoter.PMID 17623662Read ↗

GTP binding by class II transactivator: role in nuclear import.Semantic proximity Read ↗

Self-association of CIITA and its transactivation potential.Semantic proximity Read ↗

Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.Semantic proximity Read ↗

CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.Semantic proximity Read ↗

Identification of a nuclear export sequence in the MHC CIITA.Semantic proximity Read ↗

CREB and phospho-CREB interact with RFX5 and CIITA to regulate MHC class II genes.Semantic proximity Read ↗

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.Semantic proximity Read ↗

Importance of class II transactivator leucine-rich repeats for dominant-negative function and nucleo-cytoplasmic transport.Semantic proximity Read ↗

The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator.Semantic proximity Read ↗

Induction of MHC class I expression by the MHC class II transactivator CIITA.Semantic proximity Read ↗

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.