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Article

GTP binding by class II transactivator: role in nuclear import.

Science (New York, N.Y.) - 27 Aug 1999

Harton J A, Cressman D E, Chin K C, Der C J, Ting J P

Abstract excerpt

Class II transactivator (CIITA) is a global transcriptional coactivator of human leukocyte antigen-D (HLA-D) genes. CIITA contains motifs similar to guanosine triphosphate (GTP)-binding proteins. This report shows that CIITA binds GTP, and mutations in these motifs decrease its GTP-binding and transactivation activity. Substitution of these motifs with analogous sequences from Ras restores CIITA function. CIITA...

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Topics

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Share to Adenosine Triphosphate
Share to COS Cells
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Guanosine Triphosphate

Share to HLA-DR Antigens

Share to Trans-Activators

Share to Transcriptional Activation

Source

Identifiers

PMID: 10464099
DOI: 10.1126/science.285.5432.1402

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GTP binding by class II transactivator: role in nuclear import.PMID 10464099Read ↗

GTP-dependent recruitment of CIITA to the class II major histocompatibility complex promoter.Semantic proximity Read ↗

Self-association of CIITA and its transactivation potential.Semantic proximity Read ↗

Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.Semantic proximity Read ↗

Identification of a nuclear export sequence in the MHC CIITA.Semantic proximity Read ↗

CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.Semantic proximity Read ↗

Regulation of transcription by a protein methyltransferase.Semantic proximity Read ↗

Phospholipase Cdelta1 is a guanine nucleotide exchanging factor for transglutaminase II (Galpha h) and promotes alpha 1B-adrenoreceptor-mediated GTP binding and intracellular calcium release.Semantic proximity Read ↗

MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator.Semantic proximity Read ↗

Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene.Semantic proximity Read ↗

Importance of class II transactivator leucine-rich repeats for dominant-negative function and nucleo-cytoplasmic transport.Semantic proximity Read ↗

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.Semantic proximity Read ↗

Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A.Semantic proximity Read ↗

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