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Article

Sensitive ELISA detection of amyloid-beta protofibrils in biological samples.

Journal of neurochemistry - 1 Oct 2007

Englund Hillevi, Sehlin Dag, Johansson Ann-Sofi, Nilsson Lars N G, Gellerfors Pär, Paulie Staffan, Lannfelt Lars, Pettersson Frida Ekholm

Abstract excerpt

Amyloid-beta (Abeta) protofibrils are known intermediates of the in vitro Abeta aggregation process and the protofibrillogenic Arctic mutation (APPE693G) provides clinical support for a pathogenic role of Abeta protofibrils in Alzheimer's disease (AD). To verify their in vivo relevance and to establish a quantitative Abeta protofibril immunoassay, Abeta conformation dependent monoclonal antibodies were generated....

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Source

Identifiers

PMID: 17623042
DOI: 10.1111/j.1471-4159.2007.04759.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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