Article
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
Science (New York, N.Y.) - 27 May 1994
Suzuki N, Cheung T T, Cai X D, Odaka A, Otvos L, Eckman C, Golde T E, Younkin S G
Abstract excerpt
Normal processing of the amyloid beta protein precursor (beta APP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid beta protein (A beta) that forms insoluble fibrillar deposits in Alzheimer's disease. Human neuroblastoma (M17) cells transfected with con...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Culture Media, Conditioned
- Enzyme-Linked Immunosorbent Assay
- Humans
- Mutation
- Neuroblastoma
- Transfection
- Tumor Cells, Cultured