Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

Science (New York, N.Y.) - 27 May 1994

Suzuki N, Cheung T T, Cai X D, Odaka A, Otvos L, Eckman C, Golde T E, Younkin S G

Abstract excerpt

Normal processing of the amyloid beta protein precursor (beta APP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid beta protein (A beta) that forms insoluble fibrillar deposits in Alzheimer's disease. Human neuroblastoma (M17) cells transfected with constructs expressing wild-type beta APP or the beta APP717 mutants linked to familial Alzheimer's disease were compared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Enzyme-Linked Immunosorbent Assay

Share to APP gene

Share to Mutation

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8191290
DOI: 10.1126/science.8191290

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.PMID 8191290Read ↗

Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.Semantic proximity Read ↗

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain.Semantic proximity Read ↗

Generation and regulation of beta-amyloid peptide variants by neurons.Semantic proximity Read ↗

The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.Semantic proximity Read ↗

Normal Cellular Processing of the β‐Amyloid Precursor Protein Results in the Secretion of the Amyloid β Peptide and Related Molecules<sup>a</sup>Semantic proximity Read ↗

Cellular mechanisms of beta-amyloid production and secretion.Semantic proximity Read ↗

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.Semantic proximity Read ↗

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.Semantic proximity Read ↗

Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide.Semantic proximity Read ↗

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.Semantic proximity Read ↗

Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.Semantic proximity Read ↗

Mass Spectrometric Characterization of Amyloid-β Species in the 7PA2 Cell Model of Alzheimer's DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.