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Article

A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.

Neurobiology of aging - 1 Sept 2009

Philipson Ola, Hammarström Per, Nilsson K Peter R, Portelius Erik, Olofsson Tommie, Ingelsson Martin, Hyman Bradley T, Blennow Kaj, Lannfelt Lars, Kalimo Hannu, Nilsson Lars N G

Abstract excerpt

Amyloid-beta (Abeta) is a major drug target in Alzheimer's disease. Here, we demonstrate that deposited Abeta is SDS insoluble in tgAPP-ArcSwe, a transgenic mouse model harboring the Arctic (E693G) and Swedish (KM670/671NL) APP mutations. Formic acid was needed to extract the majority of deposite...

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Source

Identifiers

PMID: 18192084
DOI: 10.1016/j.neurobiolaging.2007.11.022

Genes

APP
SDS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18192084-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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