The Arctic mutation interferes with processing of the amyloid precursor protein.

doi:10.1097/00001756-200210280-00005

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Article

The Arctic mutation interferes with processing of the amyloid precursor protein.

Neuroreport - 28 Oct 2002

Stenh Charlotte, Nilsberth Camilla, Hammarbäck Josefin, Engvall Benita, Näslund Jan, Lannfelt Lars

Abstract excerpt

The Arctic amyloid precursor protein (APP) Alzheimer mutation, is located inside the beta-amyloid (Abeta) domain. Here, hybrid APP mutants containing both the Swedish and the Arctic APP mutations were investigated. ELISA measurements of cell media showed decreased levels of both Abeta40 and Abeta42. Similar results were obtained for the Dutch and Italian mutations, whereas the Flemish mutation displayed increased...

Topics

Alzheimer Disease
Amyloid Precursor Protein Secretases
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Arctic Regions
Aspartic Acid Endopeptidases
Brain
Brain Chemistry
Cells, Cultured
Culture Media

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Down-Regulation

Endopeptidases

Gene Expression Regulation

Humans

Mutation

Peptide Fragments

Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 12395079
DOI: 10.1097/00001756-200210280-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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