Article
Amyloid beta-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation.
Neuroscience letters - 27 Oct 1995
Lannfelt L, Basun H, Vigo-Pelfrey C, Wahlund L O, Winblad B, Lieberburg I, Schenk D
Abstract excerpt
The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-containing plaques and neurofibrillary tangles. The main constituent of senile plaques is amyloid beta-peptide (A beta) and in recent years, pathogenic mutations in the amyloid precursor protein (APP) gene have been discovered in some AD families. The APP670/671 mutation, found in a Swedish AD family, has revealed over-production of A beta as...
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