Article
Arylamine N-acetyltransferase activity in human cultured cell lines.
The Biochemical journal - 1 Sept 1993
Coroneos E, Sim E
Abstract excerpt
Many arylamine and hydrazine drugs and xenobiotics are acetylated by liver N-acetyltransferase (NAT; EC 2.3.1.5). Two loci, mnat and pnat, encode the enzymes designated monomorphic and polymorphic NAT (mNAT and pNAT) respectively. These isoenzymes have different substrate specificities. In additi...
Topics
- Acetylation
- Amino Acid Sequence
- Arylamine N-Acetyltransferase
- Base Sequence
- Carcinoma, Hepatocellular
- DNA
- Gene Expression
- Genotype
- Humans
- Isoenzymes
- Liver Neoplasms
- Molecular Sequence Data
- Polymerase Chain Reaction
- Substrate Specificity
- Tumor Cells, Cultured