Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral differences among 129 substrains: implications for knockout and transgenic mice.

Behavioral neuroscience - 1 Aug 2002

Cook Melloni N, Bolivar Valerie J, McFadyen Melanie P, Flaherty Lorraine

Abstract excerpt

Most knockout (KO) mice are produced with embryonic stem cells derived from a 129 strain. Because most KO strains are backcrossed to B6 yet retain a portion of their genome from 129, especially around the ablated target locus, phenotypes previously attributed to the ablated locus may be due to passenger 129 genes. Thus, the authors decided to test several 129 substrains for their behavioral characteristics. Seven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Behavior, Animal
Share to Fear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maze Learning

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Reproducibility of Results

Source

Identifiers

PMID: 12148927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral differences among 129 substrains: implications for knockout and transgenic mice.PMID 12148927Read ↗

Genetic and behavioral differences among five inbred mouse strains commonly used in the production of transgenic and knockout mice.Semantic proximity Read ↗

Survey of embryonic stem cell line source strains in the water maze reveals superior reversal learning of 129S6/SvEvTac mice.Semantic proximity Read ↗

Behavioral differences among fourteen inbred mouse strains commonly used as disease models.Semantic proximity Read ↗

Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain.Semantic proximity Read ↗

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice.Semantic proximity Read ↗

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies.Semantic proximity Read ↗

Behavioural differences between C57BL/6 and 129S6/SvEv strains are reinforced by environmental enrichment.Semantic proximity Read ↗

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.Semantic proximity Read ↗

Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies.Semantic proximity Read ↗

Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains.Semantic proximity Read ↗

Revised nomenclature for strain 129 mice.Semantic proximity Read ↗

The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.