Article
A male-specific QTL for social interaction behavior in mice mapped with automated pattern detection by a hidden Markov model incorporated into newly developed freeware.
Journal of neuroscience methods - 30 Aug 2014
Arakawa Toshiya, Tanave Akira, Ikeuchi Shiho, Takahashi Aki, Kakihara Satoshi, Kimura Shingo, Sugimoto Hiroki, Asada Nobuhiko, Shiroishi Toshihiko, Tomihara Kazuya, Tsuchiya Takashi, Koide Tsuyoshi
Abstract excerpt
BACKGROUND: Owing to their complex nature, social interaction tests normally require the observation of video data by a human researcher, and thus are difficult to use in large-scale studies. We previously established a statistical method, a hidden Markov model (HMM), which enables the differentiation of two social states ("interaction" and "indifference"), and three social states ("sniffing", "following", and...
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