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Article

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2013

Corbin Karen D, Abdelmalek Manal F, Spencer Melanie D, da Costa Kerry-Ann, Galanko Joseph A, Sha Wei, Suzuki Ayako, Guy Cynthia D, Cardona Diana M, Torquati Alfonso, Diehl Anna Mae, Zeisel Steven H

Abstract excerpt

Choline metabolism is important for very low-density lipoprotein secretion, making this nutritional pathway an important contributor to hepatic lipid balance. The purpose of this study was to assess whether the cumulative effects of multiple single nucleotide polymorphisms (SNPs) across genes of choline/1-carbon metabolism and functionally related pathways increase susceptibility to developing hepatic steatosis....

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Identifiers

PMID: 23292069
DOI: 10.1096/fj.12-219097
PMCID: PMC3606533

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.PMID 23292069Read ↗

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