Article

Constitutively active TrkB kinase signalling reduces actin filopodia dynamics and cell migration

2020-09-12

Abstract excerpt

Trk receptors and gene fusions of NTRK are targets in precision oncology. Classical Trk signalling concepts fail to explain ligand-independent signalling of intracellular TrkB or NTRK fusion proteins. Here, we show that abundance of the intracellular domain of TrkB is sufficient for ligand-independent autophosphorylation. This constitutive TrkB signalling reduced actin filopodia dynamics, could phosphorylate FAK...

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Literature Corpus work: b3edfcca-ccd0-5c28-84c4-b044196a1cc0
DOI: 10.1101/2020.09.11.292565

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