Article
Xenobiotic responsive element in the 5'-upstream region of the human P-450c gene.
Journal of biochemistry - 1 Aug 1991
Kubota M, Sogawa K, Kaizu Y, Sawaya T, Watanabe J, Kawajiri K, Gotoh O, Fujii-Kuriyama Y
Abstract excerpt
The nucleotide sequence of the 5'-upstream region up to about -4.1 kb of the human P-450c gene was determined. Two kinds of repetitive sequences were located; one was the Alu sequence which was inserted at three positions (-3127 to -3038, -3017 to -2770, and -2167 to -1851), and the other was the SINE-R element located just upstream of the most distal Alu sequences. The region other than the two repeated...
Topics
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Cytochrome P-450 Enzyme System
- Humans
- Methylcholanthrene
- Molecular Sequence Data
- Mutation
- Plasmids
- Transfection