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Article

Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.

Molecular pharmacology - 1 Oct 2012

Yamauchi John G, Gomez Kimberly, Grimster Neil, Dufouil Mikael, Nemecz Akos, Fotsing Joseph R, Ho Kwok-Yiu, Talley Todd T, Sharpless K Barry, Fokin Valery V, Taylor Palmer

Abstract excerpt

The acetylcholine-binding proteins (AChBPs), which serve as structural surrogates for the extracellular domain of nicotinic acetylcholine receptors (nAChRs), were used as reaction templates for in situ click-chemistry reactions to generate a congeneric series of triazoles from azide and alkyne building blocks. The catalysis of in situ azide-alkyne cycloaddition reactions at a dynamic subunit interface facilitated...

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Identifiers

PMID: 22784805
DOI: 10.1124/mol.112.080291
PMCID: PMC3463225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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