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Article

Rational understanding of nicotinic receptors drug binding.

Current topics in medicinal chemistry - 1 Jan 2004

Grutter Thomas, Le Novère Nicolas, Changeux Jean-Pierre

Abstract excerpt

The atomic determination of the acetylcholine binding protein (AChBP), a molluscan cholinergic protein, homologous to the amino-terminal extracellular domain of nicotinic receptors (nAChRs), offers opportunities for the modeling of the acetylcholine binding site and its ligands. Recently, we constructed three-dimensional models of the N-terminal part of nAChR and docked in the putative ligand-binding pocket,...

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Source

Identifiers

PMID: 14965300
DOI: 10.2174/1568026043451177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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