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Article

The binding orientation of epibatidine at α7 nACh receptors.

Neuropharmacology - 1 Apr 2017

Thompson Andrew J, Metzger Simon, Lochner Martin, Ruepp Marc-David

Abstract excerpt

Epibatidine is an alkaloid toxin that binds with high affinity to nicotinic and muscarinic acetylcholine receptors, and has been extensively used as a research tool. To examine binding interactions at the nicotinic receptor, it has been co-crystallised with the structural homologue acetylcholine binding protein (AChBP; PDB ID 2BYQ), and with an AChBP chimaera (3SQ6) that shares 64% sequence identity with the α7...

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Identifiers

PMID: 28089847
DOI: 10.1016/j.neuropharm.2017.01.008
PMCID: PMC5390772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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